Stem Cell Institute Philippines

novel inductions for the future...

Stem Cell Treatment for Macular Degeneration is an Option at ASCI



macular degeneration and stem cell therapy

Photobiodulation Inhibits Long-Term Structural and Functional Lesions of Diabetic Retinopathy. Diabetes. 2017 Nov 22;: Authors: Cheng Y, Du Y, Liu H, Tang J, Veenstra A, Kern TS Abstract Previous studies demonstrated that brief (3-4 minutes), daily application of light at 670nm to diabetic rodents inhibited molecular and pathophysiologic processes implicated in the pathogenesis of diabetic retinopathy (DR), and reversed diabetic macular edema in small numbers of patients studied. Whether or not this therapy would inhibit the neural and vascular lesions that characterize the early stages of the retinopathy was unknown. We administered photobiomodulation (PBM) therapy daily for 8 months to streptozotocin-diabetic mice, and assessed effects of PBM on visual function, retinal capillary permeability, and capillary degeneration using published methods. Vitamin D receptor and Cyp24a1 transcripts were quantified by qRT-PCR, and the abundance of c-Kit(+) stem cells in blood and retina were assessed. Long-term daily administration of PBM significantly inhibited the diabetes-induced leakage and degeneration of retinal capillaries, and significantly inhibited also the diabetes-induced reduction in visual function. PBM also inhibited diabetes-induced reductions in retinal Cyp24a1 mRNA levels and numbers of circulating stem cells (CD45(-)/c-Kit(+)), but these effects may not account for the beneficial effects of PBM on the retinopathy. PBM significantly inhibits the functional and histopathologic features of early DR, and these effects likely are mediated via multiple mechanisms. PMID: 29167189 [PubMed - as supplied by publisher]
Nicotinamide: a novel treatment for age-related macular degeneration? Stem Cell Investig. 2017;4:86 Authors: Westenskow PD PMID: 29167807 [PubMed]